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Promising HIV Prevention Drug

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Researchers are currently looking into a prevention drug, which could be given every one to three months as alternative to the daily pills that some people take now to cut their risk of getting HIVThe experimental drug has only been tested on monkeys, but it completely protected them from infection in two studies reported at an AIDS conference on Tuesday, 4th March.

“This is the most exciting innovation in the field of HIV prevention that I’ve heard recently, both groups are showing 100 percent protection. If it works and proves to be safe, it would allow for HIV to be prevented with periodic injections, perhaps every three months.

Dr. Robert Grant, an AIDS expert at the Gladstone Institutes.

 

A drug used to treat people with HIV, are also used to help prevent infection in people who don’t have the virus. A big study in gay men a few years ago found it could cut this risk by up to 90 percent, depending on how faithfully people take the daily pills. The new research tested something that could make this type of prevention much more practical — a long-acting experimental drug made by GlaxoSmithKline PLC.

Researchers at the Centres for Disease Control and Prevention gave six monkeys shots of the drug every four weeks; six others got dummy shots. All were exposed to the virus twice a week for 11 weeks. The monkeys who got the fake treatment were readily infected “but the animals that received the long-acting drug remained protected,” said study leader Gerardo Garcia-Lerma of the CDC. The results mirror what was seen in the CDC’s early research in monkeys on Truvada, the pill that’s available for HIV prevention now.

In the second study, Chasity Andrews and others at the Aaron Diamond AIDS Research Center at Rockefeller University in New York gave eight monkeys two shots of the drug, four weeks apart, and dummy shots to eight others. The animals were exposed to the virus weekly for eight weeks. Again, all animals given the fake treatment were quickly infected and those on the drug were all protected.

To see how long a single shot would last, they did a second study. The single shot protected 12 monkeys for about 10 weeks on average.

The dose used in a single shot corresponded to what people would get from a shot every three months, researchers said.

“This is really promising,” said Dr. Judith Currier, an infectious disease specialist at the University of California, Los Angeles. The research “supports moving this forward” into human testing, she said.

Currier is on the program committee for the meeting in Boston where the studies were presented — the Conference on Retroviruses and Opportunistic Infections. The New York study also was published online by the journal Science.

Grant said the long-acting drug is chemically similar to certain AIDS medicines sold now that are “extremely safe, well tolerated and extremely potent.” A mid-stage trial testing the long-acting shots in people as a treatment, not a prevention, is already underway, he said.

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